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Oxidized LDL

“Cardiovascular disease accounts for the majority of deaths in cohorts of patients with non-alcoholic steatohepatitis”1

Patients with NAFLD or NASH have increased small dense LDL and an increased risk of cardiovascular disease. Small dense LDL are highly atherogenic due to their susceptibility to becoming oxidized (oxLDL).

“cholesterol and its oxidized form play a crucial role in the progression of NAFLD”2

“oxLDL is an important trigger for NASH development”2

1. Armstrong MJ et al. (2017) Lancet 387: 679-690.
2. Walenbergh SM et al. (2013) J Hepatol. 58:801-810